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1C; P <0.05) but not the lowest dose of KCl (P= 0.32). The vasodilator responses when quantified as a per cent change from rest were slightly augmented with combined l-NMMA and ketorolac infusion at all doses of KCl (Fig. 1D). ACh infusion resulted in significant increases in FVC from rest (2.7 �(Added: Sat Mar 03 2018)

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0001). Similar results were obtained in Hela cells (Supplementary Figure S5; P<0.0001). To understand whether the enhancement of cell death in p53 knockdown HCT116 cells under hypoxia was mediated by p53 suppression of BNIP3, we further conducted cotransfection experiments by taking advantage of dom(Added: Sat Mar 03 2018)

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