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Pressbox (Press Release) - Five patients underwent heart or heart-lung transplantation, 4 of whom subsequently died. Among patients with diagnoses of pulmonary hypertension, 46% died during follow-up, compared with 6.7% of those without this diagnosis. In multivariate analysis, age <30 days at BAVP (hazard ratio [HR]: 5.7; 95% confidence interval [CI]: 3.2 to 10.1; p <0.001), presence of multiple left-sided obstructive lesions (HR: 11.9; 95% CI: 5.9 to 24.4; p <0.001), and BAVP during the first decade of experience (HR: 5.9; 95% CI: 2.3 to 15.1; p <0.001) were the only pre-procedural or acute post-procedural PFI 2 predictors of subsequent cardiovascular death. Of the 63 deaths in the entire cohort, 6 were considered SUD (Table 6). Five of these patients died at ��18 months of age and 3 at <2 months of age. Only 1 SUD occurred in the group ��4 years of age at most recent follow-up, a 28-year-old asymptomatic patient who was restricted from competitive sports, who died suddenly during sleep. Thus, the minimal incidence of SUD in the cohort ��4 years of age was 18 of 100,000 patient-years (95% CI: 1 of 100,000 to 101 of 100,000). Although patient follow-up for the purpose of SUD was censored at time of AVR or transplantation by study design, SUD did not occur learn more in any patients censored for this reason. In this long-term observational cohort of 528 patients who underwent BAVP for congenital AS, we found an extremely low rate of SUD; there were only 6 cases in more than 6,300 patient-years of follow-up. Although the small number of patients with SUD precluded formal statistical analysis for associated variables, Selleck MG132 SUD was more common in the young, with 5 of 6 cases occurring in infants ��18 months of age and 3 of the 6 cases in those ��45 days of age. Patients with neonatal AS requiring BAVP early in life may thus be at higher risk than older children for SUD, a finding that has not been reported to date and may have implications for clinical follow-up. Among patients ��4 years of age at most recent follow-up, in whom exercise restriction could reasonably be postulated to have a beneficial or protective effect, we found only a single occurrence of SUD in more than 6,000 patient-years of follow-up. Cumulative patient-years of follow-up were roughly similar in the group of patients restricted in any fashion from exercise and those unrestricted (2,541 patient-years vs. 2,691 patient-years), and we could find no differences between these groups in baseline characteristics (such as age at initial BAVP, frequency of associated cardiovascular anomalies, or pre-intervention AS gradient), or acute procedural results (post-intervention AS gradient, degree of AR).Submitted by: