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Pressbox (Press Release) - Thyroxine (reference interval: 19��3 to 51��5 nmol/L) and in many cases also thyroid-stimulating hormone concentrations (reference interval: <0��30 ng/mL) were measured initially and after changing the diet. Results: Twelve dogs were presented with a median age of five years. The median plasma thyroxine concentration was 156��1 (range of 79��7 to 391��9) nmol/L; in six dogs, thyroid-stimulating hormone concentration was measured and was <0��03 ng/mL in five dogs and 0��05 ng/mL in one dog. Six dogs showed clinical signs such as weight loss, aggressiveness, tachycardia, panting and restlessness R428 while six dogs had no clinical signs. After changing the diet eight dogs were examined: thyroxine concentration normalised in all dogs and clinical signs resolved. Clinical Significance: Dietary hyperthyroidism can be seen in dogs on a raw meat diet or fed fresh or dried gullets. Increased plasma thyroxine concentration in a dog, either with or without signs of hyperthyroidism, should prompt the veterinarian to obtain a thorough dietary history. While hypothyroidism is a common endocrine disorder in dogs, hyperthyroidism is a rare disease in this species. Although functional thyroid adenomas have been described, hyperthyroidism in dogs is almost always caused by a thyroid carcinoma (Feldman and Nelson 2004). In the 1960s, 17% of all canine malignant tumours in Germany were of thyroidal origin, whereas 50 years later only about 2% are thyroidal tumours (Kessler and Smeak 2005). Of all thyroidal tumours only approximately 10% are functional and produce thyroid hormones (Turrel and others 2006). Exogenous Everolimus price hyperthyroidism, a result of excessive intake of thyroid hormones, is uncommon in dogs and may result from excessive administration of sodium levothyroxine (Feldman and Nelson 2004). In human medicine, excessive consumption of meat contaminated with thyroid tissue has resulted in exogenous hyperthyroidism (Malvinder and Sturge 2003, Conrey and other 2008, Hendriks and Looij 2010) but this has so far not been reported in dogs. Clinical signs of increased thyroxine concentration are similar to those buy Palbociclib seen in cats, such as weight loss, polyphagia, unkempt haircoat, patchy alopecia and polyuria/polydipsia (Mathes and Neiger 2010, Rijnberk and Koistra 2010). A current trend among dog owners is the feeding of ��natural�� diets. Proponents argue that the processing methods used to produce commercial pet foods destroy essential nutrients and enzymes (Joffe and Schlesinger 2002). They believe that commercial pet foods do not meet the nutritional needs of dogs and may be a source of chronic health problems (Joffe and Schlesinger 2002). A natural diet widely used in Germany is commonly termed BARF (born again raw feeders, bones and raw foods, biologically appropriate raw foods).Submitted by: