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Never Forget When You Could Simply Get The Latest Pifithrin-?? Completely Free, But You Decided Not

Added: (Sat Mar 03 2018)

Pressbox (Press Release) - Secondary endpoint was in-stent restenosis (ISR). Stent thrombosis (ST) served as a safety endpoint. ST, myocardial infarction, cardiac death, target lesion revascularization (TLR), and TVR were defined Ruxolitinib according to the Academic Research Consortium definition (15). We hypothesized that the rate of a 1-year MACE rate would be 5% in the DK crush and 15% in the Culotte groups. Accordingly, a total sample size of 358 was needed to detect a power of 0.8 (Type II error = 0.20, �� = .05, 2-tailed). Because of the considerable uncertainty, the enrollment was extended to 420 patients (15% increment). The treatment-group differences were evaluated with a student t test or Wilcoxon rank sum scores for continuous variables when appropriate. The chi-square test or the Fisher exact test was used to analyze categorical variables. Rate-free survival from events were generated by Kaplan-Meier analysis, and they were compared using the log-rank test. Four pre-specified subgroup analyses by Forest plot were planned to be performed. Statistical significance was taken as a p value <0.05. All analyses were performed with the statistical program SPSS version 16.0 (SPSS Institute Inc., Chicago, Illinois). Baseline clinical (Table 1), lesions (Table 2), and procedural (Table 3) characteristics were well matched between 2 treatment groups. All continuous variables were normally distributed. By 12-month follow-up, there were 34 (16.3%) composite MACEs in the Culotte group and 13 (6.2%) in the DK group (p = 0.001), mainly because of significantly increased TLR (6.7%) and TVR (11%) in the Culotte group (2.4%, p = 0.037) compared Pifithrin-α datasheet check details with the DK group (4.3%, p = 0.016) (Table 4, Figure 3, Figure 4?and?Figure 5). Among patients with distal bifurcation angle ��70��, NERS (New Risk Stratification) score ��20 and SYNTAX score ��23, the incidence of the composite MACE in the DK group was significantly lower than that in the Culotte group (Fig. 6). By 12 months, the incidence of definite ST was 1.0% (n = 2) in the Culotte group and 0% in the DK group (p = 0.623). There were 12 (6.8%) ISR at side branch (SB) in the DK group and 22 (12.6%) in the Culotte group (p = 0.037), mostly seen at ostial SB (Table 5). The major finding was that Culotte stenting was associated with significantly increased 1-year composite MACE rate, mainly because of the increment of TVR rate. For UPLMCA bifurcation lesions, single-stent strategy was superior to systematic double-stent (including V-stenting, kissing stenting) techniques (3, 4, 5?and?6). Actually, Culotte stenting is a reverse T stenting, by which intraprocedural acute closure of the main vessel after stenting SB is unavoidable (14?and?16), this rate was 1% in the present study, which might be catastrophic for distal left main, as we showed that 1 patient died soon after LAD closure.

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