Added: (Thu Apr 18 2019)
Pressbox (Press Release) -
The 2,2-Dimethyl-3-hydroxypropanal is a white powder. The temperature of 89-90 ° C, the boiling point of 172-173 ° C, molecular formula: C5H10O2.
2,2-Dimethyl-3-hydroxypropanal was prepared by adding 630 g of a 37% aqueous formaldehyde solution and 340 g of anhydrous potassium carbonate to a reaction flask equipped with a stirrer, a thermometer, a dropping funnel and a reflux condenser. . Under vigorous stirring, 500 g (6.94 mol) of isobutyraldehyde was slowly added dropwise, and the reaction temperature was controlled at 15 to 20 °C. After the addition, the reaction was stirred for 3 hours. The layers were allowed to stand, and the lower aqueous layer (recovery of potassium carbonate) was laminated, and after cooling, the oil layer 2,2-dimethyl-3-hydroxypropanal was solidified.
The main use of 2,2-dimethyl-3-hydroxypropanal is the intermediate of the vitamin drug calcium pantothenate. Can also be used in other organic synthesis.