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3-Hydroxy-2,2-dimethylpropanal

Added: (Thu Apr 18 2019)

Pressbox (Press Release) - The 2,2-Dimethyl-3-hydroxypropanal is a white powder. The temperature of 89-90 C, the boiling point of 172-173 C, molecular formula: C5H10O2.

2,2-Dimethyl-3-hydroxypropanal was prepared by adding 630 g of a 37% aqueous formaldehyde solution and 340 g of anhydrous potassium carbonate to a reaction flask equipped with a stirrer, a thermometer, a dropping funnel and a reflux condenser. . Under vigorous stirring, 500 g (6.94 mol) of isobutyraldehyde was slowly added dropwise, and the reaction temperature was controlled at 15 to 20 C. After the addition, the reaction was stirred for 3 hours. The layers were allowed to stand, and the lower aqueous layer (recovery of potassium carbonate) was laminated, and after cooling, the oil layer 2,2-dimethyl-3-hydroxypropanal was solidified.

The main use of 2,2-dimethyl-3-hydroxypropanal is the intermediate of the vitamin drug calcium pantothenate. Can also be used in other organic synthesis.

Submitted by:Gerhold Lin
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